I prefer to define this plugin as a “grid builder” instead of a page builder, because a page builder is commonly intended as a tool that allows to create sections and, usually, comes with shortcodes such as tabs, accordions, particular sections, galleries etc… And, in many cases, all these shortcodes are not compatible with other similar plugins you prefer to use.
PixGridder is instead very simple, because it only allows to split your page (or post or custom post, you can decide it) in rows and columns, simply by moving the functions available on your tinyMCE editor from the whole page to each column you decide to split your page in. In this way you can use the plugins you prefer with the shortcodes you prefer (and also the buttons available on your tinyMCE editor) since the editor it is exactly the same one you would have without using PixGridder.
They’re invisible except through the source code. So if you want to disable the plugin you don’t have to worry about a lot of strange and unuseful shortcodes across your content because everything will stay hidden to the search engine robots too.
However, if you want to remove any trace of the plugin from the source code, you can do it by enabling the “no trace” option, so, when you delete the plugin from your plugin list, all the options and all the comments related to it will be removed, but you’ll keep unaltered your content.